Description
This e-book introduces the reader to biomolecules and describes the experimental and theoretical aspects of their micro- and nano-scale motion in water. Particular emphasis is given to their transport in engineered micro-environments where they are driven by externally imposed electric fields. Envisaged application technologies of this wide-ranging science involve healthcare, food provisioning, environmental services, etc. The e-book is generally intended for undergraduate students studying chemical, life, physical and engineering sciences, and also interdisciplinary researchers.
Preface
The micro- and nano- transport of biomolecules is of interest to a wide range of scientific and engineering communities. Application areas include miniaturized technology that will support and advance key sectors, including healthcare, food provisioning, environment services, etc. This ebook is generally intended for undergraduate students from chemical, life and physical sciences wanting to find out about the basic properties of biomolecules and how they can be transported in liquids on the micro- to nano-scale. The e-book tends to be oriented towards engineering aspects, especially with the transport of biomolecules in micro-devices powered electrically. It is hoped it will also be useful for interdisciplinary researchers surveying the field of biomolecule transport.
Much of the book can be read with no more than high school level of science and mathematics and selected areas that require engineering mathematics can be omitted if need be. Vector notation for example has been deliberately omitted until Chapter 4. At the same time the more mathematical sections in Chapter 4 are expected to be useful for researchers entering this area of science.
Content
Introduction
Motivation: biomolecules in scientific context
Length scale of transport
Biomolecule transport example: engineered microdevices
Structure of this e-book
Biomolecules and their electrical properties
Biomolecules in cells
Biomolecules: structure and function
Biomolecules: electrical properties
Concluding remarks
Moving biomolecules using electric fi elds
Electrophoresis
Dielectrophoresis (DEP)
Micro-environments for biomolecule transport
Concluding remarks
Basic micro- and nano-transport
Inertial, friction and sedimentation forces on single biomolecules
Electromagnetic forces acting on single biomolecules
Thermal fl uctuations
Combining forces for predicting single bioparticle trajectory
Langevin equation for a single bioparticle (biomolecule)
Langevin equation stochastic integration and the modifi ed diffusion equation (MDE)
Concluding remarks
Observing, quantifying and simulating electrically driven biomolecule microtransport
Micro-device and experimental arrangement
Observations and quantitative measurements
Simulations of electrically driven biomolecule micro-transport
Brief discussion of experiments and theory
Concluding remarks
References
General – selected books
Research articles and other reading
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